Krystal Beily created a new blog entry
on December 27 at 04:02 AM public
Antibody-Drug Conjugates: New Strategies of ADC Payloads
The concept of ADCs was first proposed by Nobel Prize winner Paul Ehrlich in 1913. But it was not until 1975, when hybridoma technology began to be used to produce monoclonal antibodies, that the...
Krystal Beily created a new blog entry
on December 27 at 03:53 AM public
Exploration of Terpenoid Biosynthesis in Filamentous Fungi
Using synthetic biology methods allows for the more efficient production of highly complex drug molecules compared to traditional chemical methods, with increased stability and controllability....
Krystal Beily created a new blog entry
on December 27 at 03:47 AM public
CMC Regulatory Considerations for ADCs
Antibody drug conjugates (ADCs)are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs have...
Krystal Beily created a new blog entry
on December 27 at 03:46 AM public
Hybridization-ELISA in the Bioassay of Oligonucleotide Drugs
Introduction ofOligonucleotides Oligonucleotide-based therapeutics represent a rapidly advancing field in current drug development. According to their therapeutic mechanisms, oligonucleotide...
Krystal Beily created a new blog entry
on November 24 at 02:27 AM public
BOC Sciences Celebrates Nobel Prize Awarded to Scientists Behind COVID-19 Vaccines
BOC Sciences expressed its congratulations to Katalin Karikó and Drew Weissmanfor being recipients of the 2023 Nobel Prize in Physiology or Medicine. The Royal Swedish Academy of...
Krystal Beily created a new blog entry
on November 24 at 02:25 AM public
Discovery of Molecular Glue Degraders
Background The use of small molecules to selectively regulate the function of proteins is the cornerstone of the development of medicine. However, only about 20% of proteins in human proteomes...
Krystal Beily created a new blog entry
on November 24 at 02:25 AM public
Biotin PEG
What are Biotinylation and Biotinylated PEG? Biotinylation is the process of covalently attaching biotin to molecules (such as amino acids, peptides, antibodies, or proteins). Due to the small...
Krystal Beily created a new blog entry
on November 24 at 02:23 AM public
Development of mRNA-Directed Delivery - LNP Delivery System
During the COVID-19pandemic, the success of mRNA vaccineshas greatly propelled the development of mRNA therapeutics. mRNA is a negatively charged nucleic acid that serves as a template for...
Krystal Beily created a new blog entry
on November 24 at 02:21 AM public
Bispecific Antibodies and Bispecific Antibody ADCs
With the rapid development of antibody-drug conjugate(ADC), more and more companies have entered the field of ADC research and development, and various types of ADC technologies and branches...
Krystal Beily created a new blog entry
on November 24 at 02:16 AM public
Advances in siRNA Drug Research
siRNA, with a molecular weight of about 13 kDa, recruits the RNA-induced silencing complex (RISC) to mRNA through base pairing, thereby inhibiting protein translation. The mRNA is targeted for...
Krystal Beily created a new blog entry
on October 25 at 10:28 PM public
mRNA Strategies for Cancer Immunotherapy
Cancer immunotherapy holds enormous potential in combating malignant tumors. Messenger ribonucleic acid (mRNA) has emerged as a widely studied tool in recent years, functioning within the...
Krystal Beily created a new blog entry
on October 25 at 10:27 PM public
Lipid Nanoparticles (LNPs) Design and Formulation Production
Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore...
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