Introduction of The Incapacitance Analgesia Test

The incapacitance analgesia test assesses the degree of pain through balance regulation in the rodent's own standing posture. When a normal rat or mouse stands, its weight is evenly distributed on the paws. And when one paw is injured or inflamed, the experimental animal will adjust the standing posture to distribute the force of different paws, thereby reducing pain. The incapacitance analgesia meter developed using this principle can automatically and reproducibly measure the force on both paws to accurately detect pain in rodents.

Fig. 1 Incapacitance Analgesia Test.

Features of The Incapacitance Analgesia Test

• Spontaneous pain was assessed by non-pain-inducing test methods without the application of any experimental noxious or non-noxious stimuli.
• Animal stress or subjectivity problems that may be caused by other testing modalities were overcome.
• It is easy to operate and can be automatically repeated multiple times to evaluate the pain relief effect.

Applications of The Incapacitance Analgesia Test

• The incapacitance analgesia test has a wide range of applications including arthritis, cartilage degeneration, incision recovery, inflammatory models, nerve or tissue damage, neuropathic lesions, and many other disease-induced pain responses or inflammatory conditions.
• Evaluation of the efficacy of analgesic and anti-inflammatory drugs.